Doctor Stephen Vincent Strange, M.D., Ph.D is the former Sorcerer Supreme and Master of the Mystic Arts. Originally being a brilliant but arrogant neurosurgeon, Strange got into a car accident which resulted with his hands becoming crippled. Once Western medicine failed him, Strange embarked on a journey to Kamar-Taj, where he was trained by the Ancient One in the ways of Magic and the Multiverse.
Although he focused on healing his hands, Strange was drawn into a conflict with Kaecilius and the Zealots, who were working for Dormammu and had sought to merge Earth with the Dark Dimension to find an eternal life. Following the demise of the Ancient One and the defeat of Kaecilius, Strange then became the new protector for the Sanctum Sanctorum, seeking to defend the Earth from other inter-dimensional threats.From his new position, Strange aided Thor in locating Odin, before he learned of Thanos' attempts to gain all of the Infinity Stones and cause a universal genocide. Since Strange was the protector of the Time Stone, he was attacked and captured by Thanos' Black Order, only for him to then be rescued by Iron Man and Spider-Man. Having also been joined by the Guardians of the Galaxy, Strange battled against Thanos. However, as Strange had seen into the future and knew his only path to victory, he had willing handed over the Time Stone, allowing Thanos to enact the Snap, killing Strange and trillions of other lives.
However, Strange and all the rest of Thanos' victims had been resurrected five years later by the Avengers, and battled against an alternate Thanos, which resulted with Iron Man sacrificing his life to save the universe.
Strange offered his aid to Spider-Man, whose identity of Peter Parker was unmasked by Mysterio, as he asked Strange to make the world forget this. However, due to Parker's interference, the spell soon went wrong, and Strange inadvertently unleashed enemies of Spider-Man from across the Multiverse. Capturing these enemies, Strange tried to use the Macchina di Kadavus to send them to their universes to meet their inevitable fates, which Spider-Man had refused to allow, hoping to give these people a chance at redemption.
Having been trapped in the Mirror Dimension, Strange then returned and fought to contain the Multiversal rift. With no other choice, Strange cast a spell to return the visitors back to their universes and close the rifts, but also at the cost of making everyone, including himself, forget Parker's existence.